MK-677 (Ibutamoren) – Growth Hormone & Recovery | 10mg, 90 caps

MK-677 (Ibutamoren): The Ultimate Growth Hormone Secretagogue

DISCLAIMER: For research purposes only. Not for human or veterinary use.

MK-677 (Ibutamoren) is a potent, long-acting, orally active growth hormone secretagogue. While often mistaken for a SARM, it technically belongs to a class of compounds that mimic the action of the hunger hormone, ghrelin. By stimulating the ghrelin receptor, MK-677 triggers the natural release of Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-1) without suppressing natural testosterone levels.

Chemical & Biological Properties

• IUPAC Name: 2-amino-2-methyl-N-[1-(1-methylsulfonylspiro[2H-indole-3,4'-piperidine]-1'-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide
• CAS Number: 159634-47-6
• Molecular Formula: C₂₇H₃₆N₄O₅S
• Molar Mass: 528.67 g/mol
• Elimination Half-Life: 4–6 hours (IGF-1 levels remain elevated for up to 24 hours)
• Mechanism: Binds to ghrelin receptors (GHSR) in the brain, triggering the pituitary gland to release GH pulses.

Potential Research Benefits

• Hypertrophy: Effectively increases lean muscle mass and strength via elevated IGF-1 levels.
• Optimized Recovery: Significantly enhances REM sleep and slow-wave sleep, leading to superior physical and mental recovery.
• Bone Density Improvement: Enhances bone mineral density, a primary focus in osteoporosis research.
• Fat Oxidation: Aids in maintaining muscle mass while utilizing stored body fat for energy.
• Anti-Aging Properties: Boosts cell regeneration and skin elasticity by restoring GH levels to youthful peaks.

Recommended Cycling Protocols

MK-677 is unique because it is non-hormonal, allowing for longer cycles compared to SARMs or anabolic steroids.

1. Standard Cycle Duration

• Beginner: 8–12 weeks at 10 mg/day.
• Intermediate: 12–16 weeks at 15–20 mg/day.
• Advanced: 16–24 weeks at 20–25 mg/day (Higher doses increase the risk of side effects).

2. Goal-Specific Stacking

• Bulking: 15–25 mg/day. Often stacked with LGD-4033 (Ligandrol) or RAD-140 (Testolone) for massive tissue growth.
• Cutting: 10–15 mg/day. Often paired with Cardarine (GW-501516) to maintain fullness while shredding fat.

Detection & Half-Life Information

While the elimination half-life is relatively short (4–6 hours), the secondary elevation of IGF-1 remains traceable and active in the body for up to 24 hours, supporting a once-daily dosing schedule.

Side Effects & Risks

• Increased Appetite: Due to ghrelin mimicry, strong hunger cravings are common.
• Water Retention: Temporary bloating or edema may occur, especially in the first few weeks.
• Insulin Sensitivity: Long-term use may impact glucose metabolism; periodic monitoring is advised.
• Cortisol Levels: May slightly increase cortisol (stress hormone), potentially impacting immune function in sensitive subjects.

Post-Cycle Therapy (PCT)

Is PCT required? No. MK-677 does not suppress natural testosterone production, so traditional PCT is unnecessary. However, a 4-week break after long cycles (16+ weeks) is recommended to reset GH receptor sensitivity.

Product Specification: (MK-677)

Serving Size: 1 Capsule
Servings Per Container: 90

* Daily Value (DV) not established.